It was in art that the spirit of the Renaissance achieved its sharpest formulation. Art came to be seen as a branch of knowledge, valuable in its own right and capable of providing man with images of God and his creations as well as with insights into man's position in the universe. In the hands of men like Leonardo da Vinci it was even a science, a means for exploring nature and a record of discoveries. Art was to be based on the observation of the visible world and practiced according to mathematical principles of balance, harmony, and perspective, which were developed at this time. In the works of painters such as Masaccio, the brothers Lorenzetti, Fra Angelico, Botticelli, Perugino, Piero della Francesca, Raphael, and Titian; sculptors such as Pisano, Donatello, Verrocchio, Ghiberti, and Michelangelo; and architects such as Alberti, Brunelleschi, Palladio, Michelozzo, and Filarete, the dignity of man found expression in the arts.
[Renaissance art] encouraged a revival of naturalism, seen in Italian 15th-century painting and sculpture, and of classical forms and ornament in architecture, such as the column and round arch, the tunnel vault, and the dome.

An important contributor to knowledge of and interest in plants was Carolus Clusius (Charles de l'Ecluse) who introduced the tulip and other bulbous plants to Holland. From these beginnings, The Netherlands has become now a premier producer and exporter of horticultural products.
As interest in plants grew, both from a botanical and horticultural perspective, exploreres throughtout the known world sent new and interesting plants to Botanical Gardens in Padua, Italy; Oxford and Kew, England; Edinburgh, Scotland; and Leiden, Holland. These gardens became great centers of scientific learning and as well as of horticultural practice.
These explorers represent a major movement that grew out of the Renaissance and that transformed Western Europe and the world: The Age of Discovery.
Many new plants in Europe came from the New World; some, such as Virginia creeper, goldenrod, Sweetgum, Staghorn Sumac, and flowering Dogwood came from the American Colonies.