HCS Spring 2016 Seminar Series

Jan 27, 2016, 11:30am - 12:30pm
244 Kottman Hall (Columbus) video-linked to 121 Fisher Auditorium (Wooster)
Dr. David Mackey
David Mackey
Department of Horticulture and Crop Science
Molecular Genetics, CAPS
The Ohio State University 

“Studies of model and crop plants reveal molecular and system level functions of a conserved family of bacterial virulence proteins.” 

Abstract: Plant-pathogenic bacteria use type III secretion to deliver so-called type III effector proteins (T3Es) into the cytosol of host cells. T3Es of the AvrE-family are unique in their broad distribution amongst and strong contribution to the virulence of diverse genera of bacteria. However, despite this widespread contribution to a variety of agriculturally relevant plant diseases, little is known about the mechanism of action or functional outputs of AvrE-family T3Es. A multifaceted examination of two different AvrE-family T3Es from pathogens of the model plant Arabidopsis thaliana and maize is revealing molecular details of their initial interaction with the host via targeting host phosphatases as well as a system level view of their effects on hose gene expression, including mis-regulation of host enzymes and resulting metabolic changes that contribute to pathogen virulence.