Dr. Leah McHale

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Dr. Leah McHale

Associate Professor

mchale.21@osu.edu

https://mchalelab.cfaes.ohio-state.edu

https://plantbreeding.cfaes.ohio-state.edu

(614) 292-9003

Office:

312B Kottman Hall, Columbus

Professional Information

Degrees & Credentials:

Ph.D., University of California, Davis, Plant Biology (2008)

B.S., The Pennsylvania State University, Horticulture (2001)

Research Area(s):

Soybean Breeding & Genetics

Genetics of Disease Resistance & Quality

Biography:

Research Emphasis

Research in the McHale lab focuses on the characterization and manipulation of natural variation occurring in crop plants, primarily soybean and chile peppers. Specifically, the research program is involved in the identification of genes conferring disease resistance, yield, and quality traits and, in soybean, examining how best to integrate these alleles for the development of improved varieties. To accomplish this, new technologies and a cross-disciplinary approach are exploited, which includes genetics and genomics, evolution, bioinformatics, and plant pathology. Particular interests are the study of breeding methodologies, disease resistance, domestication and agronomic traits for both the development of improved cultivars and evolutionary and molecular plant-pest interactions studies.

Teaching Responsibilities

Plant Genetics (HCS 4325), 3 credit spring semester undergraduate course, co-taught with Dr. David Mackey.

Plant Breeding and Biotechnology (HCS 7625), 3 credit autumn semester graduate course, co-taught with Dr. John Finer.

Methods in Horticulture and Crop Science (HCS 7806), 1 credit graduate course, taught spring of alternate years. Topics have included ‘Multimedia Communication’ and ‘Bioinformatic Analysis of eQTL Data.’

Current topics in Horticulture and Crop Science (HCS 8830), 1 credit graduate course, taught spring of alternate years. Topics have included ‘Molecular Basis for Domestication’ and ‘Genetic Analysis of Quantitative Resistance.’

Colloquium (HCS 7890), 1 credit graduate course offered in spring and fall.

Works

Recent Publications (Last 5 years)

Lee S, Jun T-H, McHale LK, Michel AP, Dorrance AE, Mian MAR (2017) Registration of the Wyandot × PI 567301B soybean recombinant inbred line population. Journal of Plant Registrations. doi: 10.3198/jpr2016.09.0042crmp.

Mian MAR, Zenglu L, Boerma HR, McHale L, Dorrance A (2017) Registration of ‘Highpro1’ soybean with high protein and high yield developed from a north x south cross. Journal of Plant Registrations. 11(1):51-54.

Van K, McHale LK (2017) Meta-analyses of QTLs associated with protein and oil contents and compositions in soybean [Glycine max (L.) Merr.] seed. International Journal of Molecular Science. 18:1180.

Gunadi A, Rushton PJ, McHale LK, Gutek A, Finer JJ (2016) Characterization of 40 soybean (Glycine max) promoters, isolated from across 5 thematic gene groups. Plant Cell, Tissue & Organ Culture. doi: 10.1007/s11240-016-1038-x.

Mian MAR, McHale LK, Michel AP, Dorrance AE (2016) Registration of ‘Wyandot-14’ Soybean with resistance to soybean aphid and powdery mildew. Journal of Plant Registrations. 10: 246-250.

Parra L, Maisonneuve B, Schut J, Christopoulou M, Jeuken M, McHale L, Truco M-J, Crute I, Michelmore R (2016) Rationalization of genes for resistance to Bremia lactucae in lettuce. Euphytica. 210: 309-326.

Schneider R, Rolling W, Song Q, Cregan P, Dorrance AE, McHale LK (2016) Genome-wide association mapping of partial resistance to Phytophthora sojae in soybean plant introductions from the Republic of Korea. BMC Genomics. 17:607.

Stasko A, Wickramasinghe D, Nauth B, Acharya B, Ellis M, Taylor C, McHale L, Dorrance A (2016) High density mapping of resistance QTL towards Phytophthora sojae, Pythium irregulare, and Fusarium graminearum in the same soybean population. Crop Science. 56: 1-17.

Zhang N, McHale LK, Finer JJ (2016) A leader intron of a soybean elongation factor 1A (eEF1A) gene interacts with proximal promoter elements to regulate gene expression in synthetic promoters. PloS one. 11:e0166074.

Acharya B*, Lee S*, Mian MAR, Jun T-H, McHale LK, Michel AP, Dorrance AE (2015) Identification and mapping of quantitative trait loci (QTL) conferring resistance to Fusarium graminearum from soybean PI 567301B. Theoretical and Applied Genetics. 128: 827-838.

Benzle KA, Finer KR, Marty DM, McHale LK, Goodner BW, Taylor CG, Finer JJ (2015) Isolation and characterization of novel Agrobacterium strains for soybean and sunflower transformation. Plant Cell, Tissue and Organ Culture. 121: 71-81.

Christopuolou M*, McHale LK*, Kozik A, Reyes-Chin Wo S, Wroblewski T, Michelmore RW (2015) Dissection of two complex clusters of resistance genes in lettuce (Lactuca sativa). Molecular Plant-Microbe Interactions. 28: 751-765.

Christopoulou M, Reyes-Chin Wo S, Kozik A, McHale LK, Truco M-J, Wroblewski T, Michelmore RW (2015) Genome-wide architecture of disease resistance genes in lettuce. G3: Genes, Genomes, Genetics. 5: 2655-2669.

Fallen BD, Allen FL, Kopsell DA, Saxton AM, McHale L, Shannon JG, Kantartzi SK, Cardinal AJ, Cregan PB, Hyten DL. Pantalone VR (2015) Selective genotyping for marker assisted selection strategies for soybean yield improvement. Plant Genetics, Genomics, and Biotechnology. 2: 95-119.

King JL, Finer JJ, McHale LK (2015) Development and optimization of agroinfiltration for soybean. Plant Cell Reports. 34: 133-140.

Lee S, Freewalt KR, McHale LK, Song Q, Jun T-H, Michel AP, Dorrance AE, Mian MAR (2015) A high-resolution genetic linkage map of soybean based on 357 recombinant inbred lines genotyped with BARCSoySNP6K. Molecular Breeding. 35: 58.

Zhang N, McHale LK, Finer JJ (2015) Isolation and characterization of “GmScream” promoters that regulate highly expressing soybean (Glycine max Merr.) genes. Plant Science. 241: 189-198.

Anderson JE, Kantar MB, Kono TY, Fu F, Stec AO, Song Q, Cregan PB, Specht JE, Diers BW, Cannon SB, McHale LK, Stupar RM (2014) A roadmap for functional structural variants in the soybean genome. G3: Genes| Genomes| Genetics. 4(7):1307-18.

Huang M, Kaletunc G, St. Martin S, Feller M, McHale LK (2014) Correlations of seed traits with tofu texture in 48 soybean cultivars and breeding lines. Plant Breeding. 133: 67-73.

Lee S, Mian MAR, Sneller C, Wang H, AE Dorrance, McHale LK (2014) Joint QTL analysis for partial resistance to Phytophthora sojae in soybean using six nested soybean recombinant inbred populations with heterogeneous conditions. Theoretical and Applied Genetics. 127:429-444.

Rincker K, Nelson R, Specht J, Sleper D, Cary R, Cianzio S, Casteel S, Conley S, Chen P, Davis V, Fox C, Graef G, Godsey C, Holshouser D, Jian G-L, Kantartzi SK, Kenworthy W, Lee C, Mian R, McHale L, Naeve S, Orf J, Poysa V, Schapaugh W, Shannon G, Uniatowski R, Wang D, Diers B (2014) Genetic improvement of soybean in maturity groups II, III, and IV. Crop Science. 54: 1-14.

Atkinson LD, McHale LK, Truco M-J, Hilton HW, Lynn J, Schut J, Michelmore RW, Hand P, Pink DAC (2013) An intra-specific linkage map of lettuce (Lactuca sativa) and genetic analysis of post-harvest discolouration traits. Theoretical and Applied Genetics. 126:2737-2752.

Ellis ML, McHale LK, Paul PA, St. Martin SK, Dorrance AE (2013) Soybean germplasm resistant to Pythium irregulare and molecular mapping of resistance quantitative trait loci derived from the soybean accession PI 424354. Crop Science. 53:1008-1021.

Lee S, Mian MAR, McHale LK, Sneller CH, Dorrance AE (2013) Identification of quantitative trait loci conditioning partial resistance to Phytophthora sojae in soybean PI 407861A. Crop Science. 53:1022-1031.

Lee S, Mian MAR, McHale LK, Wang H, Wijeratne A, Sneller CH, Dorrance AE (2013) Novel quantitative trait loci for partial resistance to Phytophthora sojae in soybean PI 398841. Theoretical and Applied Genetics. 126:1121-1132.

McHale LK, Feller MK, McIntyre SA, Berry SA, St. Martin SK, Dorrance AE (2013) Registration of 'Summit', a high-yielding soybean with race-specific resistance to Phytophthora sojae. Journal of Plant Registrations 7:36-41.

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Dr. Leah McHale

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Professional Information

Research Emphasis

Teaching Responsibilities

Recent Publications (Last 5 years)